2019

REBERNIK, Mateja, SNOJ, Tina, KLEMENČIČ, Marina, NOVINEC, Marko. Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I. Archives of Biochemistry and Biophysics, 2019, in press, doi: 10.1016/j.abb.2019.108121.

STRAŠEK, Nika, LAVRENČIČ, Lara, OŠTREK, Andraž, SLAPŠAK, Dejan, GROŠELJ, Uroš, KLEMENČIČ, Marina, BRODNIK ŽUGELJ, Helena, WAGGER, Jernej, NOVINEC, Marko, SVETE, Jurij. Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorganic chemistry, 2019, vol. 89, 102982, doi: 10.1016/j.bioorg.2019.102982

REBERNIK, Mateja, LENARČIČ, Brigita, NOVINEC, Marko. The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease. Protein expression and purification, 2019, vol. 157, p. 21-27. doi: 10.1016/j.pep.2019.01.009

PETEK, Nejc, ŠTEFANE, Bogdan, NOVINEC, Marko, SVETE, Jurij. Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors. Bioorganic chemistry, 2019, vol. 84, p. 226-238, doi: 10.1016/j.bioorg.2018.11.029

2018

PORODKO, Andreas, CIRNSKI, Ana, PETROV, Dražen, RAAB, Teresa, PAIREDER, Melanie, MAYER, Bettina, MARESCH, Daniel, NIKA, Lisa, BINIOSSEK, Martin L., GALLOIS, Patrick, SCHILLING, Oliver, OOSTENBRINK, Chris, NOVINEC, Marko, MACH, Lukas. The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities. Biological chemistry, vol. 399, iss. 10, p. 1223-1235. doi: 10.1515/hsz-2018-0186

LUKIĆ, Branislav, GROŠELJ, Uroš, NOVINEC, Marko, SVETE, Jurij. Synthesis of novel 5-(N-Boc-N-benzyl-2-aminoethyl)-7-oxo- 4, 7-dihydropyrazolo[1,5-a]pyrimidin-3-carboxamides and their inhibition of cathepsins B and K. Acta chimica slovenica, 2017, vol. 64, no. 4, p. 782-789. doi: 10.17344/acsi.2017.3421.

GORIČAN, Tjaša, NOVINEC, Marko. Uravnavanje encimov s ciljanjem alosteričnih mest : primer katepsina K. Proteus : ilustriran časopis za poljudno prirodoznanstvo, feb. 2018, letn. 80, [št.] 6, str. 265-271, 287. [in Slovene]

PETEK, Nejc, NOVINEC, Marko, SVETE, Jurij. Novi derivati 5-aminoalkil-7-okso-4,7-dihidropirazolo[1,5-a]pirimidin-3-karboksilnih kislin kot inhibitorjev katepsina K in postopek priprave : SI25288 (A), 2018-04-30. Ljubljana: Urad RS za intelektualno lastnino, 2018. 17 f., 1 f. pril. [patent] [in Slovene]

2017

HIRA, Vashendriya V. V., VERBOVŠEK, Urška, BREZNIK, Barbara, SRDIČ, Matic, NOVINEC, Marko, KAKAR, Hala, WORMER, Jill, SWAAN, Britt van der, LENARČIČ, Brigita, JULIANO, Luiz, MEHTA, Shwetal, NOORDEN, Cornelis J. F. van, LAH TURNŠEK, Tamara. Cathepsin K cleavage of SDF-1[alpha] inhibits its chemotactic activity towards glioblastoma stem-like cells. Biochimica et biophysica acta. BBA, Molecular cell research, 2017, vol. 1864, no. 3, p. 594-603, doi: 10.1016/j.bbamcr.2016.12.021.

PAIREDER, Melanie, THOLEN, Stefan, PORODKO, Andreas, BINIOSSEK, Martin L., MAYER, Bettina, NOVINEC, Marko, SCHILLING, Oliver, MACH, Lukas. The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B. Biochimica et biophysica acta, Proteins and proteomics, 2017, vol. 1865, iss. 4, p. 444-452, doi: 10.1016/j.bbapap.2017.02.007.

NOVINEC, Marko. Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases. PloS one, Aug. 2017, vol. 12, no. 8, art. no. e0182387 (p. 1-22), doi: 10.1371/journal.pone.0182387.

2016

PAIREDER, Melanie, MEHOFER, Urlich, THOLEN, Stefan, PORODKO, Andreas, SCHÄHS, Philipp, MARESCH, Daniel, BINIOSSEK, Martin L., HOORN, Ranier van der Hoorn, LENARČIČ, Brigita, NOVINEC, Marko, SCHILLING, Oliver, MACH, Lukas. The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity. Archives of biochemistry and biophysics, 2016, vol. 603, p. 110-117, doi: 10.1016/j.abb.2016.05.017

NIEMER, Melanie, MEHOFER, Urlich, VERDIANZ, Maria, PORODKO, Andreas, SCHÄHS, Philipp, KRACHER, Daniel, LENARČIČ, Brigita, NOVINEC, Marko, MACH, Lukas. Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease. Biochimie, 2016, vol. 122, p. 119-125, doi: 10.1016/j.biochi.2015.06.017.

NOVINEC, Marko, REBERNIK, Mateja, LENARČIČ, Brigita. An allosteric site enables fine-tuning of cathepsin K by diverse effectors. FEBS letters, 2016, vol. 590, iss. 24, p. 4507-4518, doi: 10.1002/1873-3468.12495.

2015

KORENČ, Matevž, LENARČIČ, Brigita, NOVINEC, Marko. Human cathepsin L, a papain-like collagenase without proline specificity. FEBS journal, 2015, vol. 282, iss. 22, p. 4328-4340, doi: 10.1111/febs.13499.

KLEMENČIČ, Marina, NOVINEC, Marko, DOLINAR, Marko. Orthocaspases are proteolytically active prokaryotic caspase homologues : the case of Microcystis aeruginosa. Molecular microbiology, 2015, vol. 98, iss. 1, p. 142-150, doi: 10.1111/mmi.13110.

2014

NOVINEC, Marko, LENARČIČ, Brigita, TURK, Boris. Cysteine cathepsin activity regulation by glycosaminoglycans. Biomed research international, 2014, vol. 2014, p. 309718-1-309718-9, doi: 10.1155/2014/309718.

NOVINEC, Marko, LENARČIČ, Brigita, BAICI, Antonio. Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiers. PloS one, 2014, vol. 9, no. 9, art. no. e106642 (p. 1-11), doi: 10.1371/journal.pone.0106642

NOVINEC, Marko. Objava v Nature communications Nov pristop k računalniško podprtemu načrtovanju učinkovin : nov pristop v spopadu z osteoporozo?. Delo, 27. feb. 2014, letn. 56, št. 48, str. 14. [in Slovene]

NOVINEC, Marko, KORENČ, Matevž, CAFLISCH, Amedeo, RANGANATHAN, Rama, LENARČIČ, Brigita, BAICI, Antonio. A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods. Nature communications, feb. 2014, vol. 5, art. no. 3287 (p. 1-10), doi: 10.1038/ncomms4287

2013

NOVINEC, Marko, LENARČIČ, Brigita. Cathepsin K : a unique collagenolytic cysteine peptidase. Biological chemistry, 2013, vol. 394, no. 9, p. 1163-1179. doi: 10.1515/hsz-2013-0134

NOVINEC, Marko, LENARČIČ, Brigita. Papain-like peptidases : structure, function, and evolution. Biomolecular concepts, vol. 4, issue 3, p. 287-308, doi: 10.1515/bmc-2012-0054

KLEMENČIČ, Marina, NOVINEC, Marko, MAIER, Silke, HARTMANN, Ursula, LENARČIČ, Brigita. The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. PloS one, 2013, vol. 8, no. 2, art. no. e56839 (12 p.), doi: 10.1371/journal.pone.0056839.

BAICI, Antonio, NOVINEC, Marko, LENARČIČ, Brigita. Kinetics of the interaction of peptidases with substrates and modifiers. V: BRIX, Klaudia (ur.), STÖCKER, Walter (ur.). Proteases : structure and function. Wien: Springer-Verlag. cop. 2013, p. 37-84, doi: 10.1007/978-3-7091-0885-7_2 [book chapter]

2012

TORKAR, Ana, BREGANT, Sarah, DEVEL, Laurent, NOVINEC, Marko, LENARČIČ, Brigita, LAH TURNŠEK, Tamara, DIVE, Vincent. A novel photoaffinity-based probe for selective detection of cathepsin L active form. ChemBioChem : a European journal of chemical biology, 2012, vol. 13, issue 17, p. 2616-2621. doi: 10.1002/cbic.201200389.

NOVINEC, Marko, LENARČIČ, Brigita, BAICI, Antonio. Clusterin is a specific stabilizer and liberator of extracellular cathepsin K. FEBS letters, 2012, vol. 586, no. 7, p. 1062-1066, doi: 10.1016/j.febslet.2012.03.004.

NOVINEC, Marko, PAVŠIČ, Miha, LENARČIČ, Brigita. A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli. Protein expression and purification, vol. 82, no. 1, p. 1-5, doi: 10.1016/j.pep.2011.11.002

2010

NOVINEC, Marko, KOVAČIČ, Lidija, LENARČIČ, Brigita, BAICI, Antonio. Conformational flexibility and allosteric regulation of cathepsin K. Biochemical journal, 2010, vol. 429, no. 2, p. 379-389, doi: 10.1042/BJ20100337.

KOVAČIČ, Lidija, NOVINEC, Marko, PETAN, Toni, KRIŽAJ, Igor. Structural basis of the significant calmodulin-induced increase in the enzymatic activity of secreted phospholipases A2A2. Protein engineering, design & selection : PEDS, 2010, vol. 23, no. 6, p. 479-487, doi: 10.1093/protein/gzq019.

2009

KOVAČIČ, Lidija, NOVINEC, Marko, PETAN, Toni, BAICI, Antonio, KRIŽAJ, Igor. Calmodulin is a non-essential activator of secretory phospholipase A2. Biochemistry, 2009, vol. 48, no. 47, p. 11319-11328, doi: 10.1021/bi901244f

2008

BUBIK, Anja, SEDMAK, Bojan, NOVINEC, Marko, LENARČIČ, Brigita, LAH TURNŠEK, Tamara. Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria. Biological chemistry, issue 10, vol. 389, p. 1339-1346, doi: 10.1515/BC.2008.153.

NOVINEC, Marko, KOVAČIČ, Lidija, ŠKRLJ, Nives, TURK, Vito, LENARČIČ, Brigita. Recombinant human SMOCs produced by in vitro refolding : calcium-binding properties and interactions with serum proteins. Protein expression and purification, issue 1, vol. 62, p. 75-82, doi: doi:10.1016/j.pep.2008.07.009.

2007

NOVINEC, Marko, GRASS, Robert N., STARK, Wendelin J., TURK, Vito, BAICI, Antonio, LENARČIČ, Brigita. Interaction between human cathepsins K, L, and S, Mechanism of elastinolysis and ihibition by macromolecular inhibitors. The Journal of biological chemistry, 2007, vol. 282, no. 11, p. 7893-78902.  doi: 10.1074/jbc.M610107200

2006

NOVINEC, Marko, KORDIŠ, Dušan, TURK, Vito, LENARČIČ, Brigita. Diversity and evolution of the thyroglobulin type-1 domain superfamily. Molecular biology and evolution, 2006, vol. 23, p. 744-755.  doi: 10.1093/molbev/msj082

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