We investigate the molecular basis of life with focus on the structure, function and evolution of proteins and their regulation by small molecules and macromolecules.

Our main research topics are:

Molecular mechanisms of allosteric regulation and cooperativity in papain-like cysteine peptidases, and

Identification and characterization of novel protein/small molecule interactions with focus on the discovery of novel antibiotics and anti-cancer drugs.

More details are found here.


Mateja successfully defended her PhD thesis. Congratulations and all the best at your new job!

Mateja’s paper “Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I” was just accepted for publication in Archives of Biochemistry and Biophysics. The online version is available here.

Mateja’s paper “The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease” will appear in press. Congratulations!
The online version is available here.

Group website launched!