Protein interactions and re-design group
University of Ljubljana, Faculty of Chemistry and Chemical Technology
Drug discovery. Enyzme engineering. Tool development.
Research focus – TwinCatcher
A versatile and easy-to-use system for the detection, modulation and engineering of homophilic protein-protein interactions in Escherichia coli.
Latest publications
Review paper on Cathepsin C/DPPI published in Rare Disease and Orphan Drugs Journal.
Read the full text here.
Cooperativity in E. coli threonine dehydrogenase and its inhibition by a pyrazole derivative with antimicrobial properties.
Full text here.
Review paper on the versatility of protease activity regulation published in IJMS.
Find the full text here.
Research projects
Research focus – enzyme engineering
Project COOPERATE
Engineering of cooperative peptidases
Research focus – enzyme engineering
Oligomeric states and evolution of cathepsin C/DPPI
Research focus – enzyme engineering
Engineering of enzymes for complete PET depolymerization
Research focus – drug design
Sirtuin 6 activation to boost longevity
Research focus – drug design
Project PRISM
PRotein Interactions with Small Molecules
Research focus – drug design
Allosteric regulation of papain-like cysteine peptidases
