We investigate the molecular basis of life with focus on the structure, function and evolution of proteins and their regulation by small molecules and macromolecules.


Our main research topics are:

Molecular mechanisms of allosteric regulation and cooperativity in papain-like cysteine peptidases, and

Identification and characterization of novel protein/small molecule interactions with focus on the discovery of novel antibiotics and anti-cancer drugs.

More details are found here.


GROUP NEWS

06-11-2019
Mateja successfully defended her PhD thesis. Congratulations and all the best at your new job!

10-2019
Mateja’s paper “Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I” was just accepted for publication in Archives of Biochemistry and Biophysics. The online version is available here.

05-2019
Mateja’s paper “The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease” will appear in press. Congratulations!
The online version is available here.

04-2019
Group website launched!