Protein interactions and re-design group
University of Ljubljana, Faculty of Chemistry and Chemical Technology
Drug discovery. Enyzme engineering. Tool development.
Research focus – TwinCatcher
A versatile and easy-to-use system for the detection, modulation and engineering of homophilic protein-protein interactions in Escherichia coli.
Latest publications
Review paper on Cathepsin C/DPPI published in Rare Disease and Orphan Drugs Journal.
Read the full text here.
Joint effort of MSc students and our collaborators from the Chair of Inorganic Chemistry resulted in a publication in IJMS. Full text here.
Evolutionary history of cathepsin C/DPPI investigated in our recent publication.
Find the full text here.
Research projects
Research focus – enzyme engineering
Project COOPERATE
Engineering of cooperative peptidases
Research focus – enzyme engineering
Oligomeric states and evolution of cathepsin C/DPPI
Research focus – drug design
Project PRISM
PRotein Interactions with Small Molecules
Research focus – drug design
Allosteric regulation of papain-like cysteine peptidases
